Pesticides appear in millions of different combinations in varying concentrations in our food and landscape. While various efforts are underway by researchers to create a system capable of monitoring the cocktail effect, it is unlikely that any will be sophisticated enough to accurately assess the full spectrum of health and environmental impacts of pesticide cocktails. The only way to minimise the risk to health and environment is therefore to hugely decrease our overall pesticide use, thereby reducing our exposure to pesticide cocktails.